Next Generation Sequencing (NGS) Panels
Our NGS panel portfolio tests for a wide selection of hereditary genetic conditions. They offer a fast, thorough, and cost-effective diagnostic tool for patients with distinctive clinical features.
A Targeted Approach for Testing Genetic Disorders
By streamlining our NGS panels to reflect the fast-growing knowledge of complex gene-disease associations, CENTOGENE’s NGS Panels represent start-of-the-art research – providing fast, thorough, and cost-effective diagnostic solutions for patients and their families.
Diagnosing a genetic disorder often requires analyzing multiple genes. We have designed our NGS panels to simultaneously test multiple genes associated with a particular disorder or group of disorders. Additionally, our panels include all relevant pathogenic and likely pathogenic variants (class 1 and class 2) within coding regions, regulatory sequences, and deep intronic regions. We use all publicly available databases such as HGMD and unpublished variants included in our rare disease-centric Bio/Databank to establish a diagnosis. We provide high-quality sequencing and best-in-class data analysis - interpreted and communicated in comprehensive medical reports.
When choosing one of our NGS panels, your patients will receive high-quality sequencing, best-in-class data analysis and interpretation as well as comprehensive medical reports – significantly simplifying the diagnostic process for you and your patients.
Why Choose our NGS Panels?
Easy sample submission with CentoCard®
High quality clinical interpretation powered by CENTOGENE's rare disease-centric Bio/Databank
Quick turnaround time and the strictest quality criteria
User-friendly, online ordering and tracking with CentoPortal®
Our NGS Panels
NGS Panels are recommended for patients meeting any or multiple of the following criteria:*
- Distinctive clinical features
- Family history of a particular disorder
- Multiple genes linked to condition
- Genetically heterogeneous disorders
- Well-defined disease-associated genes
* Genet Med. 2015 Jun;17(6):444-51. doi: 10.1038/gim.2014.122. Epub 2
Conclusive Clinical Reports
- Interpretation of data by experienced professionals
- Clear results of identified variants following international best-practice guidelines (ACMG and CMSS)
- Detailed method description
- References to publications supporting medical and scientific results
- Recommendations for follow-up analyses for specific diseases
- Reporting of pathogenic variants, likely pathogenic variants and VUS
Medical Reporting
Pathogenic and likely pathogenic variants are reported following ACMG classification guidelines. Variants of uncertain significance (VUS) are not reported in any of the following cases: the described phenotype(s) is explained by detected pathogenic or likely pathogenic variant(s); the detected VUS are not related to the described phenotype(s) of the patient or family members; in the lack of sufficient clinical information; and in our oncogenetic panels.
Please note that detailed and specific clinical information (preferentially phenotype/HPOs) is required for variant interpretation and medical diagnosis.
Resources
Useful Links
Downloads
NGS Panels – Handbook
A targeted approach for testing genetic disorders
Latest Webinars
Cómo los biomarcadores transforman los diagnósticos genéticos
A lo largo del seminario web, Pilar Guatibonza, MD, y Carlos Manrique, MD, brindan una descripción general de cómo los biomarcadores multiómicos desempeñan un papel esencial en el diagnóstico […]
生殖健康与產前遺傳学檢測
研討會中，我們論述了 CENTOGENE 產前篩查選項，以及產前檢測如何在孕週期時發揮關鍵作用，快速尋找答案。
How Biomarkers Transform Genetic Diagnostics
Throughout the webinar, Dr. Tobias Böttcher provided an overview of how multiomic biomarkers play an essential role in early diagnosis, prediction, and therapeutic monitoring of Niemann-Pick Disease […]
Sample Requirements
CENTOGENE accepts many different types of samples for NGS Panel tests. Please refer to our dedicated Sample Requirements page for details.
Transparency and Quality of Medical Reports
High-quality medical reporting is essential for building a partnership of trust.
Get in Touch With Our Customer Support
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